20 February: Punjab Minister for social welfare Zil-e-Huma Usman was shot and killed in Gujranwala. Her assassin, Mohammed Sarwar, was reported to have been motivated by her refusal to abide by the Islamic code of dress and a dislike for the involvement of women in political affairs.

19–22 March: Clashes between pro-government forces under Maulvi Nazir and Al-Qaeda remnants in the Waziristan region kill at least 135 people on both sides. A ceasefire is declared after four days of fighting enforced by officials from both sides.

10–11 April: Up to 35 people were killed and scores of others wounded in heavy fighting between rival Shia and Sunni (Deobandi) groups in different areas of the Kurram Agency on Tuesday night and Wednesday.

28 April: Assassination attempt on Aftab Ahmad Sherpao, who is the Interior minister that killed 28 people in Charsadda, Khyber-Pakhtunkhwa. This time again an attempt on a high ranking officer of Pakistani government was unsuccessful.

12 May: As many as 50 people were killed and hundreds injured when party workers of opposing parties; MQM, ANP and PPP clash in Karachi. The riots started when rival political rallies take the same route amid lawyers protests for restoration of Iftikhar Muhammad Chaudhry as the Chief

15 May: A bomb blast at the local Marhaba hotel in Peshawar killed at least 24 people and injured 30. No one claimed responsibility for the suspected suicide blast in the lobby of the hotel popular with Afghans in Peshawar where militants opposed to government support for the United States have launched attacks.

14 July: At least 23 paramilitary troops died and 27 others injured when a suicide bomber rammed an explosives-packed car into their convoy in Miranshah in one of the deadliest attacks on the security forces in North Waziristan.

15 July: At least 49 are killed and hundreds injured when suicide attack and car bombs explode throughout Khyber-Pakhtunkhwa in an apparent retaliation for Lal Masjid operation. 11 security personnel and six civilians were killed and 47 others injured in Matta, Swat District, when suicide bombers smashed two cars packed with explosives into an army convoy, and 25 people were killed and 61 injured when a suicide bomber blew himself up in the Dera Ismail Khan police recruitment center. The attack in Swat was the third attack on Army outside the conflict zones of FATA.

19 July: More than 40 people were killed in three separate bomb attacks. In the first incident, bomb was detonated in a mosque used by military personnel in the north-western town of Kohat, killing at least 11 people. This marked the fourth time the Army was attacked outside conflict zone since 2004. In the second one, 26 people died and 50 were injured in the southern town of Hub, Lasbela District, Balochistan, in an attack apparently targeting Chinese workers. And in the last one, at least seven people were killed and more than 20 injured in a suicide car bombing at a police academy in the north-western town of Hangu.

4 September: At least 25 people were killed and 66 injured in two suicide bomb blasts in Rawalpindi cantonment's high security areas during morning rush hour. The first blast took place near Qasim Market where a Defence Ministry bus carrying around 38 civilians and uniformed officials was hit, killing 18 people. Five minutes later, a second blast took place near RA Bazaar, behind General Headquarters. The blast was caused by explosives fixed to a motorcycle, which blew up killing seven people on the spot. This was the fifth time the Army was attacked outside war zone since the start of military operations, and the first time in Rawalpindi, the site of General Headquarters.

18 October: Attack on Benazir Bhutto convoy killed over 139 in Karachi and left more than 450 injured in one of the most deadliest terrorist attacks in Pakistan. Former PM Benazir Bhutto was returning after 8 years of self imposed exile when the bomber struck the convoy killing dozens.

17–19 November: As many as 94 people were killed and 168 injured in three days of in-fighting between the rival Sunni(Deobandi) and Shia sects in Parachinar, Kurram Agency in Pakistani tribal areas, bordering Afghanistan. Only by the fourth day, the army gained control of the area and a ceasefire was maintained in the area.

24 November: 30 people were killed in two suicide attacks in Rawalpindi. In the first incident, a suicide bomber rammed his car into a 72-seater bus parked in front of Ojhri Camp on Murree Road carrying Inter-Services Intelligence (ISI) officials to work, killing 28 officials and a bystander. The second incident occurred as a second suicide bomber attempted to enter the General Headquarters (GHQ). Upon being asked for identification at the GHQ's check post, he blew himself up, resulting in the deaths of one security official and a bystander.

21 December: On the eve of Eid ul-Adha, a suicide bomb blast again targeted Aftab Ahmad Sherpao killing at least 57 and injuring over 100 at Jamia Masjid Sherpao, in Charsadda District. Aftab Sherpao survived the blast, but his younger son Mustafa Khan Sherpao, was injured.

27 December: Two-time Prime Minister Benazir Bhutto was assassinated in a shooting and suicide bombing in Rawalpindi's Liaquat Bagh, killing up to 20 others and injuring many. The site is notorious as the place where former Prime Minister Liaquat Ali Khan was also assassinated in October 1951.

28 December: At least 33 people, including four policemen, were killed all over Pakistan in the violence that ensued after the assassination of former prime minister Benazir Bhutto. The situation grew so worse that Sindh Rangers were given orders to shoot-at-sight.