A roadside bomb blast killed 12 civilians and injured five others in Paktika province, some 155 km southeast of Afghan capital Kabul on Sunday, provincial administration confirmed in a statement.

"The tragic and gruesome incident occurred at around 10:30 a.m. (0600 GMT) in Waza Khwa district today," the statement stressed.

Those lost their precious lives in the bloody incident includes two women, five children and five men.

Governor of Paktika province Muhibullah Samim blamed "the enemies of Afghanistan", a term used by Afghan officials against Taliban militants, for planted the mine on a road that caused the bloody incident.

However, the outfit fighting Afghan and NATO-led troops has yet to make comment.

Sunday's roadside bombing is the second bloody attack of its kind in Paktika province since the beginning of 2011. A similar roadside bombing on Jan. 19 struck a vehicle in Khushamand district killing 13 civilians including women and children.

Afghan President Hamid Karzai in a statement released by his office described the attack as un-Islamic and inhuman and strongly condemned it.

"Killing innocent Afghan civilians is enmity with Afghanistan and an act goes against humanity," Afghan president said in the statement.

The NATO-led International Security Assistance Force (ISAF) in a statement released to media also condemned the deadly roadside bombing in Paktika province. "This blatant disregard for innocent Afghan lives is appalling," said Rear Admiral Vic Beck, ISAF Director of Public Affairs in the statement.

"Our thoughts and prayers go out to those who lost their lives and the surviving families and friends of those affected by this attack. We will continue to work closely with our Afghan counterparts to find those responsible and bring them to justice," NATO's statement reads.