For the first time, researchers have identified structural
damage to the lungs caused by secondhand cigarette smoke.
The results of the study, conducted by researchers at the
University of Virginia and The Children's Hospital of Philadelphia,
were presented Monday at the annual meeting of the Radiological
Society of North America (RSNA) in Chicago.
"It's long been hypothesized that prolonged exposure to
secondhand smoke may cause physical damage to the lungs, but
previous methods of analyzing lung changes were not sensitive
enough to detect it," said Chengbo Wang, magnetic resonance
physicist at The Children's Hospital of Philadelphia.
Dr. Wang and colleagues used helium-3 diffusion magnetic
resonance imaging (MRI) to study the lungs of 43 volunteers,
including seven current and former smokers and 36 people who had
never smoked, 18 of whom had a high level of exposure to secondhand
smoke.
Patients inhales a specially prepared helium gas prior to
imaging, and the scanner is adjusted to collect images showing this
helium gas in tissue. Magnetic resonance measures how far the
helium atoms move, or diffuse, inside the lungs during a specific
time period -- 1.5 seconds in this study.
Using this method, radiologists can detect changes deep in the
small airways and sacs in the lungs, which can break down, become
enlarged and develop holes after prolonged exposure to cigarette
smoke. Helium-3 diffusion MRI identifies this damage by measuring
the increased distance the helium atoms move.
"With this technique, we are able to assess lung structure on a
microscopic level," Dr. Wang said.
For the study, measurements were translated into scores called
apparent diffusion coefficient (ADC) values for each of the
participants. An increased ADC value indicates that the helium
atoms were able to travel farther during the measurement time.
Fifty-seven percent of the smokers and 33 percent of the nonsmokers
with high exposure to secondhand smoke had ADC values greater than
0.024, suggesting that early lung damage was present.
In addition, 14 percent of smokers, 67 percent of high-exposure
nonsmokers, and 39 percent of low-exposure nonsmokers had ADC
values below 0.0185. Relatively low ADC values in adults are a
possible indication of a developing respiratory problem, such as
chronic bronchitis or asthma.
"These findings suggest that breathing secondhand smoke can
injure your lungs," Dr. Wang said. "Since legislation to limit
public exposure to secondhand smoke is still being considered in
many states in U.S., we hope that our work can be used to add
momentum to the drive to pass such legislation."
(Xinhua News Agency November 27, 2007)
