CGTN:

Recently it was reported that Chinese researchers last year deleted some genome sequences of cases from the early stage of the outbreak, which had been uploaded on to the database maintained by the U.S. National Center for Biotechnology Information (NCBI). It was speculated that China has concealed some information about the origin of the virus. How would you respond to this issue? Thank you.  

Zeng Yixin: 

After it was reported, we immediately conducted an investigation. The report mentions the deletion of SARS-CoV-2 sequences, which is relevant to a paper 'Nanopore target sequencing for accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses' published by researchers from Wuhan University in the international scientific journal 'Small.' According to the title, we can tell the paper was about a sequencing method. When they made a submission last March, the sequencing results were needed. That means when a sequencing method is created, the results are needed to assure its accuracy and reliability. Therefore, the researchers uploaded their concrete sequencing results of the virus onto the database of the National Center for Biotechnology Information (NCBI), a branch of the National Institute of Health (NIH). 

On June 9, 2020, the journal sent back the researchers the proofread paper where they found the information about where they had uploaded the sequencing results of samples from confirmed cases had been deleted. The researchers thought that since the information about the sequencing was deleted, it was unnecessary to keep those sequencing results on the NCBI.

Therefore, they sent an email to the NIH to request the removal of the data on June 16, 2020. The NIH followed the protocol and deleted the data without notice. When the researchers requested the removal, the data was automatically removed without notifying the researchers. The researchers were not informed, and hence they ignored this. So it is clear that the researchers had absolutely no need, or intention, to hide or conceal any information. Recently, they uploaded all 244 pieces of sequencing data of 61 COVID-19 samples onto the GSA database built by the China National Center for Bioinformation, which is open to global researchers.

As far as we know, the earliest sampling in the case was done on Jan. 30, 2020, some time after the initial outbreak, so the sequences cannot count as early ones and thus have limited value or information regarding the study of SARS-CoV-2 origins. However, a U.S. researcher, Jesse Bloom, with the Fred Hutchinson Cancer Research Center, fabricated the conspiracy theory that this was an attempted cover-up, without any confirmation from the Chinese researchers and with absolutely no understanding the background context of the matter. His actions deviated from science and violated scientific ethics, having not only smeared the Chinese researchers, but also causing a negative effect on relevant international public opinion. After the publication, his paper has been criticized by experts from various countries for its violation of scientific ethics. During this epidemic, the public is deeply concerned about and highly sensitive to the words and deeds of professionals, especially scientists. Therefore, researchers should understand they have their own responsibility to society. Especially during the pandemic, people are highly sensitive to opinions about the disease, so we professionals should not speculate in a deceptive and unrealistic manner. This could cause bad influence on the whole society's control and prevention of the pandemic. We should instead make contributions and correctly guide public opinion. Here, I want to remind every expert to learn the lesson that experts are more than just experts; they have a responsibility to the society. This deserves recognition. Thanks.