Tokyo stocks closed mixed on Wednesday amid a cautious mood before the U.S. announcement of reciprocal tariffs.

Japan's benchmark Nikkei stock index, the 225-issue Nikkei Stock Average, ended up 101.39 points, or 0.28 percent, from Tuesday at 35,725.87.

The broader Topix index, meanwhile, finished 11.44 points, or 0.43 percent, lower at 2,650.29.

On the stock market, heavyweight semiconductor-related issues supported the benchmark Nikkei following rises by their U.S. counterparts on the Nasdaq index.

Investors remained cautious over an additional 25 percent tariff set to be imposed as planned on Thursday on all cars made outside the United States, analysts said.