Acerbic talent show judge Simon Cowell, actress Sandra Bullock, singer Lady Gaga and the pop star now known as Prince are among the most influential artists of 2010, according to Time magazine.

Comedian Conan O'Brien, Russian conductor Valery Gergiev and chef David Chang also made the annual list compiled by the magazine's senior editors.

Talk show host and media magnate Oprah Winfrey was also included in the list, which was divided into four categories -- leaders, thinkers, artists and heroes.

Winfrey, who was recognized for her achievements on Broadway, movies and publishing, has been on every list since it was started seven years ago -- more than any other Time 100 designee.

"There is no match for you in media history," former talk show host Phil Donahue wrote about Winfrey in the magazine. "You are not only hot; you are cool: the Dream Girl for millions of ambitious young women whom you've inspired all over the world."

Actor Neil Patrick Harris, popularly known as "Doogie Howser, M.D." for his childhood TV role, was recognized for his role in changing the public's perception of gay men.