Lucas Ferreira and Andre Silva scored second-half goals as Sao Paulo eased to a 2-0 win at Libertad in their Copa Libertadores group stage match on Wednesday.
Ferreira broke the deadlock just after the hour for the Brazilian club by dribbling 30 yards and slotting a composed finish into the far corner from 10 yards.
The hosts squandered a chance to equalize when Lorenzo Melgarejo sent his 70th-minute spot-kick crashing off the bar.
Andre Silva made the Paraguayan side pay, doubling his team's advantage with a looping header into the far corner following Nahuel Ferraresi's cross from the right wing.
"To score my first Copa Libertadores goal and win the match 2-0 is a great feeling. I'm grateful to our fans who made the long trip here," said 18-year-old Ferreira, who was making only his 10th first-team appearance.
"Our fans always lift us when we need them and we're grateful for that."
Sao Paulo leads Group D with seven points from three games, a point ahead of second-placed Libertad.
Elsewhere in the Copa Libertadores on Wednesday, Independiente del Valle drew 2-2 at home to River Plate, Estudiantes won 1-0 at home to Botafogo, Olimpia was held to a goalless home draw by Penarol and San Antonio prevailed 2-1 at home to Velez Sarsfield.
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